{"id":8641,"date":"2026-08-11T12:31:45","date_gmt":"2026-08-11T12:31:45","guid":{"rendered":"https:\/\/mesencell.com\/%d9%85%d9%83%d8%a7%d9%81%d8%ad%d8%a9-%d8%a7%d9%84%d8%b4%d9%8a%d8%ae%d9%88%d8%ae%d8%a9-%d8%a7%d9%84%d9%88%d9%82%d8%a7%d9%8a%d8%a9-%d9%85%d9%86-%d8%a7%d9%84%d8%a3%d9%85%d8%b1%d8%a7%d8%b6\/"},"modified":"2026-09-25T06:19:52","modified_gmt":"2026-09-25T06:19:52","slug":"%d9%85%d9%83%d8%a7%d9%81%d8%ad%d8%a9-%d8%a7%d9%84%d8%b4%d9%8a%d8%ae%d9%88%d8%ae%d8%a9-%d8%a7%d9%84%d9%88%d9%82%d8%a7%d9%8a%d8%a9-%d9%85%d9%86-%d8%a7%d9%84%d8%a3%d9%85%d8%b1%d8%a7%d8%b6","status":"publish","type":"page","link":"https:\/\/mesencell.com\/ar\/%d9%85%d9%83%d8%a7%d9%81%d8%ad%d8%a9-%d8%a7%d9%84%d8%b4%d9%8a%d8%ae%d9%88%d8%ae%d8%a9-%d8%a7%d9%84%d9%88%d9%82%d8%a7%d9%8a%d8%a9-%d9%85%d9%86-%d8%a7%d9%84%d8%a3%d9%85%d8%b1%d8%a7%d8%b6\/","title":{"rendered":"\u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 \/ \u0627\u0644\u0648\u0642\u0627\u064a\u0629 \u0645\u0646 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\u0634\u064a\u062e\u0648\u062e\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0648\u0627\u0633\u062a\u0646\u0641\u0627\u062f \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629\u060c \u0648\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0632\u0645\u0646 \u0645\u0646\u062e\u0641\u0636 \u0627\u0644\u062f\u0631\u062c\u0629 \u0627\u0644\u0645\u0639\u0631\u0648\u0641 \u0628\u0627\u0633\u0645 &#8220;\u0627\u0644\u0627\u0644\u062a\u0647\u0627\u0628 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629&#8221; \u062a\u064f\u062d\u062f \u0645\u0646 \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0645\u062a\u0648\u0642\u0639 \u0648\u0641\u062a\u0631\u0629 \u0627\u0644\u0635\u062d\u0629.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c0482ed e-con-full e-flex e-con e-parent\" data-id=\"c0482ed\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-5839606 e-flex e-con-boxed e-con e-child\" data-id=\"5839606\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-273b8ac elementor-widget elementor-widget-heading\" data-id=\"273b8ac\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"#MSCATS-section\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629 \u0648\u0625\u0641\u0631\u0627\u0632\u0627\u062a\u0647\u0627 \u0627\u0644\u062e\u0644\u0648\u064a\u0629 (\u0627\u0644\u0633\u064a\u0643\u0631\u064a\u062a\u0648\u0645) <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88c24aa elementor-widget elementor-widget-text-editor\" data-id=\"88c24aa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0644\u062d\u0645\u064a\u0629 \u0627\u0644\u0645\u062a\u0648\u0633\u0637\u0629 (MSCs) \u0647\u064a \u062e\u0644\u0627\u064a\u0627 \u0633\u062f\u0648\u064a\u0629 \u0645\u062a\u0639\u062f\u062f\u0629 \u0627\u0644\u0642\u062f\u0631\u0627\u062a\u060c \u064a\u0645\u0643\u0646\u0647\u0627 \u0627\u0644\u062a\u0645\u0627\u064a\u0632 \u0625\u0644\u0649 \u0623\u0646\u0648\u0627\u0639 \u0645\u062e\u062a\u0644\u0641\u0629 \u0645\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0645\u0643\u0648\u0646\u0629 \u0644\u0644\u0639\u0638\u0645 (osteoblasts)\u060c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u063a\u0636\u0631\u0648\u0641\u064a\u0629\u060c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629\u060c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0636\u0644\u064a\u0629\u060c \u0648\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0647\u0646\u064a\u0629. \u0648\u0642\u062f \u0648\u064f\u062b\u0651\u0650\u0642\u062a \u0647\u0630\u0647 \u0627\u0644\u0638\u0627\u0647\u0631\u0629 \u0641\u064a \u062e\u0644\u0627\u064a\u0627 \u0648\u0623\u0646\u0633\u062c\u0629 \u0645\u062d\u062f\u062f\u0629\u060c \u0633\u0648\u0627\u0621 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a (in vivo) \u0623\u0648 \u062e\u0627\u0631\u062c\u0647 (in vitro). \u062a\u062a\u0648\u0632\u0639 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u0646\u062d\u0627\u0621 \u0627\u0644\u062c\u0633\u0645 \u0648\u062a\u0644\u0639\u0628 \u062f\u0648\u0631\u0627\u064b \u0641\u064a \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u062c\u062f\u064a\u062f \u0627\u0644\u062e\u0644\u0648\u064a\u061b \u0648\u062a\u0634\u0645\u0644 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0634\u0627\u0626\u0639\u0629 \u0627\u0644\u0627\u0633\u062a\u062e\u062f\u0627\u0645 \u0644\u0639\u0632\u0644\u0647\u0627: \u0646\u062e\u0627\u0639 \u0627\u0644\u0639\u0638\u0645\u060c \u0648\u0627\u0644\u062d\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u060c \u0648\u0628\u0637\u0627\u0646\u0629 \u0627\u0644\u062d\u0628\u0644 \u0627\u0644\u0633\u0631\u064a\u060c \u0648\u0643\u0630\u0644\u0643 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0627\u0644\u062a\u064a \u062a\u062d\u0638\u0649 \u0628\u0627\u0647\u062a\u0645\u0627\u0645 \u0645\u062a\u0632\u0627\u064a\u062f \u0646\u0638\u0631\u0627\u064b \u0644\u0627\u062d\u062a\u0648\u0627\u0626\u0647\u0627 \u0639\u0644\u0649 \u0643\u0645\u064a\u0627\u062a \u0648\u0641\u064a\u0631\u0629 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627.   <\/p><p>\u062a\u062a\u0648\u0627\u0635\u0644 \u062c\u0645\u064a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u062a\u062a\u0628\u0627\u062f\u0644 \u0627\u0644\u0645\u0639\u0644\u0648\u0645\u0627\u062a \u0639\u0628\u0631 \u0637\u0631\u0642 \u0645\u062a\u0646\u0648\u0639\u0629\u060c \u062a\u0634\u0645\u0644 \u0625\u0641\u0631\u0627\u0632 \u0639\u0648\u0627\u0645\u0644 \u0642\u0627\u0628\u0644\u0629 \u0644\u0644\u0630\u0648\u0628\u0627\u0646\u060c \u0648\u0627\u0644\u0627\u0644\u062a\u0635\u0627\u0642 \u0627\u0644\u0645\u0628\u0627\u0634\u0631 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627\u060c \u0648\u0627\u0644\u062a\u0628\u0627\u062f\u0644 \u0627\u0644\u062e\u0644\u0648\u064a \u0644\u0644\u0639\u0636\u064a\u0627\u062a. \u0648\u064a\u0636\u0645 &#8220;\u0627\u0644\u0645\u0641\u0631\u064e\u0632\u0627\u062a&#8221; (secretome) \u0627\u0644\u062e\u0627\u0635\u0629 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0645\u0648\u0627\u062f\u0651\u064e \u0630\u0627\u062a \u062a\u0623\u062b\u064a\u0631 \u0646\u0638\u064a\u0631 \u0635\u0645\u0627\u0648\u064a (paracrine)\u060c \u0648\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u062e\u0627\u0631\u062c\u064a\u0629 (exosomes)\u060c \u0648\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u062f\u0642\u064a\u0642\u0629 (microvesicles)\u061b \u0625\u0630 \u064a\u0645\u0643\u0646 \u0644\u0647\u0630\u0647 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0625\u0641\u0631\u0627\u0632 \u0623\u0643\u062b\u0631 \u0645\u0646 150 \u0645\u0627\u062f\u0629 \u0630\u0627\u062a \u062a\u0623\u062b\u064a\u0631 \u0646\u0638\u064a\u0631 \u0635\u0645\u0627\u0648\u064a\u060c \u062a\u064f\u0639\u0631\u0641 \u0623\u064a\u0636\u0627\u064b \u0628\u0627\u0633\u0645 \u0627\u0644\u0633\u064a\u062a\u0648\u0643\u064a\u0646\u0627\u062a \u0648\u0627\u0644\u0643\u064a\u0645\u0648\u0643\u064a\u0646\u0627\u062a. \u0648\u0647\u0646\u0627\u0643 \u0645\u062c\u0645\u0648\u0639\u062a\u0627\u0646 \u0645\u062a\u0645\u064a\u0632\u062a\u0627\u0646 \u0645\u0646 \u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u062a\u062e\u062a\u0644\u0641\u0627\u0646 \u0645\u0646 \u062d\u064a\u062b \u0628\u0646\u064a\u0629 \u0627\u0644\u063a\u0634\u0627\u0621\u060c \u0648\u0622\u0644\u064a\u0629 \u0627\u0644\u0625\u0646\u062a\u0627\u062c\u060c \u0648\u0627\u0644\u0623\u0647\u0645\u064a\u0629 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a\u0629 \u0627\u0644\u0645\u0631\u0636\u064a\u0629\u060c \u0648\u0627\u0644\u062d\u062c\u0645.   <\/p><p>\u062a\u0645 \u0648\u0635\u0641 \u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629 \u0648\u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062f\u0642\u064a\u0642\u0629. \u062a\u062d\u062a\u0648\u064a \u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062f\u0642\u064a\u0642\u0629 \u0648\u0627\u0644\u062d\u0648\u064a\u0635\u0644\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629 \u0639\u0644\u0649 \u062c\u0632\u064a\u0626\u0627\u062a \u062d\u064a\u0648\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0631\u0633\u0648\u0644 (mRNA) \u0648\u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0627\u0644\u0631\u064a\u0628\u0648\u0632\u064a \u0627\u0644\u0645\u064a\u0643\u0631\u0648\u064a (microRNA). \u064a\u062a\u0645\u064a\u0632 \u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u062f\u0647\u0646\u064a\u0629 \u0628\u062a\u0623\u062b\u064a\u0631 \u0645\u0636\u0627\u062f \u0644\u0644\u0627\u0644\u062a\u0647\u0627\u0628\u0627\u062a \u0648\u0645\u0636\u0627\u062f \u0644\u0644\u0627\u0633\u062a\u0645\u0627\u062a\u0629\u060c \u0648\u064a\u0633\u062a\u0647\u062f\u0641 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u0629.  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-af2cc53 e-con-full e-flex e-con e-parent\" data-id=\"af2cc53\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-e70151f e-flex e-con-boxed e-con e-child\" data-id=\"e70151f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d8af82e elementor-widget elementor-widget-heading\" data-id=\"d8af82e\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"#SBFA-section\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0627\u0644\u0645\u0624\u0634\u0631\u0627\u062a \u0627\u0644\u062d\u064a\u0648\u064a\u0629 \u0641\u064a \u0627\u0644\u0644\u0639\u0627\u0628 \u0644\u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629 <\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1c373ff e-grid e-con-boxed e-con e-child\" data-id=\"1c373ff\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-96e16e6 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"96e16e6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-brain\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M208 0c-29.9 0-54.7 20.5-61.8 48.2-.8 0-1.4-.2-2.2-.2-35.3 0-64 28.7-64 64 0 4.8.6 9.5 1.7 14C52.5 138 32 166.6 32 200c0 12.6 3.2 24.3 8.3 34.9C16.3 248.7 0 274.3 0 304c0 33.3 20.4 61.9 49.4 73.9-.9 4.6-1.4 9.3-1.4 14.1 0 39.8 32.2 72 72 72 4.1 0 8.1-.5 12-1.2 9.6 28.5 36.2 49.2 68 49.2 39.8 0 72-32.2 72-72V64c0-35.3-28.7-64-64-64zm368 304c0-29.7-16.3-55.3-40.3-69.1 5.2-10.6 8.3-22.3 8.3-34.9 0-33.4-20.5-62-49.7-74 1-4.5 1.7-9.2 1.7-14 0-35.3-28.7-64-64-64-.8 0-1.5.2-2.2.2C422.7 20.5 397.9 0 368 0c-35.3 0-64 28.6-64 64v376c0 39.8 32.2 72 72 72 31.8 0 58.4-20.7 68-49.2 3.9.7 7.9 1.2 12 1.2 39.8 0 72-32.2 72-72 0-4.8-.5-9.5-1.4-14.1 29-12 49.4-40.6 49.4-73.9z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tBACE 1 (\u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0631\u0642\u0645 1 \u0627\u0644\u0642\u0627\u0637\u0639 \u0644\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0644\u0641 \u0644\u0644\u0623\u0645\u064a\u0644\u0648\u064a\u062f \u0641\u064a \u0627\u0644\u0645\u0648\u0642\u0639 \u0628\u064a\u062a\u0627)\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\u0625\u0646\u0632\u064a\u0645 \u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0625\u0646\u062a\u0627\u062c \u0631\u0648\u0627\u0633\u0628 \u0628\u0631\u0648\u062a\u064a\u0646 \u0628\u064a\u062a\u0627 \u0627\u0644\u0646\u0634\u0648\u0627\u0646\u064a \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u0648\u0627\u0644\u062a\u0646\u0643\u0633 \u0627\u0644\u0628\u0642\u0639\u064a \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0639\u0645\u0631\u060c \u0648\u0627\u0644\u0633\u0643\u0631\u064a \u0645\u0646 \u0627\u0644\u0646\u0648\u0639 \u0627\u0644\u062b\u0627\u0646\u064a\u060c \u0648\u0627\u0644\u062a\u0635\u0644\u0628 \u0627\u0644\u062c\u0627\u0646\u0628\u064a \u0627\u0644\u0636\u0645\u0648\u0631\u064a\u060c \u0648\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646. \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0646\u0647 \u0636\u0627\u0631\u0629 \u0628\u0627\u0644\u0635\u062d\u0629. \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e063abd elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"e063abd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-brain\" viewBox=\"0 0 576 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M208 0c-29.9 0-54.7 20.5-61.8 48.2-.8 0-1.4-.2-2.2-.2-35.3 0-64 28.7-64 64 0 4.8.6 9.5 1.7 14C52.5 138 32 166.6 32 200c0 12.6 3.2 24.3 8.3 34.9C16.3 248.7 0 274.3 0 304c0 33.3 20.4 61.9 49.4 73.9-.9 4.6-1.4 9.3-1.4 14.1 0 39.8 32.2 72 72 72 4.1 0 8.1-.5 12-1.2 9.6 28.5 36.2 49.2 68 49.2 39.8 0 72-32.2 72-72V64c0-35.3-28.7-64-64-64zm368 304c0-29.7-16.3-55.3-40.3-69.1 5.2-10.6 8.3-22.3 8.3-34.9 0-33.4-20.5-62-49.7-74 1-4.5 1.7-9.2 1.7-14 0-35.3-28.7-64-64-64-.8 0-1.5.2-2.2.2C422.7 20.5 397.9 0 368 0c-35.3 0-64 28.6-64 64v376c0 39.8 32.2 72 72 72 31.8 0 58.4-20.7 68-49.2 3.9.7 7.9 1.2 12 1.2 39.8 0 72-32.2 72-72 0-4.8-.5-9.5-1.4-14.1 29-12 49.4-40.6 49.4-73.9z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tUCH-L1 (\u0625\u0646\u0632\u064a\u0645 \u0647\u064a\u062f\u0631\u0648\u0644\u0627\u0632 \u0627\u0644\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0637\u0631\u0641 \u0627\u0644\u0643\u0631\u0628\u0648\u0643\u0633\u064a\u0644\u064a L1):\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\u064a\u064f\u0639\u062f \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0627\u0644\u0645\u0633\u0624\u0648\u0644 \u0639\u0646 \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0627\u0644\u0641\u0636\u0644\u0627\u062a \u0627\u0644\u0633\u0627\u0645\u0629 -\u0645\u062b\u0644 \u0628\u0631\u0648\u062a\u064a\u0646 \"\u0623\u0645\u064a\u0644\u0648\u064a\u062f \u0628\u064a\u062a\u0627\"- \u0648\u064a\u0633\u0627\u0647\u0645 \u0641\u064a \u062a\u062d\u0633\u064a\u0646 \u062d\u0627\u0644\u0627\u062a \u0636\u0639\u0641 \u0627\u0644\u0630\u0627\u0643\u0631\u0629. \u0648\u062a\u0634\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0646\u062e\u0641\u0636\u0629 \u0645\u0646\u0647 \u0625\u0644\u0649 \u062e\u0644\u0644 \u0641\u064a \u0646\u0638\u0627\u0645 \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0627\u0644\u0641\u0636\u0644\u0627\u062a \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645\u061b \u0648\u0645\u0639 \u0630\u0644\u0643\u060c \u0642\u062f \u062a\u0631\u062a\u0628\u0637 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0644\u0644\u063a\u0627\u064a\u0629 \u0628\u062d\u062f\u0648\u062b \u0625\u0635\u0627\u0628\u0629 \u0641\u064a \u0627\u0644\u062f\u0645\u0627\u063a!  \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a080aad elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"a080aad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<i aria-hidden=\"true\" class=\"ion ion-network\"><\/i>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\t\u0623\u0644\u0641\u0627-\u0633\u064a\u0646\u0648\u0643\u0644\u064a\u0646 \u0627\u0644\u0645\u064f\u0641\u0633\u0641\u0631\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\u064a\u0644\u0639\u0628 \u0627\u0644\u0637\u064a \u063a\u064a\u0631 \u0627\u0644\u0633\u0644\u064a\u0645 \u0648\u062a\u0631\u0627\u0643\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \"\u0623\u0644\u0641\u0627-\u0633\u064a\u0646\u0648\u0643\u0644\u064a\u0646\" (\u03b1-synuclein) \u0628\u0634\u0643\u0644 \u063a\u064a\u0631 \u0637\u0628\u064a\u0639\u064a \u062f\u0648\u0631\u0627\u064b \u062c\u0648\u0647\u0631\u064a\u0627\u064b \u0641\u064a \u0627\u0644\u062a\u0633\u0628\u0628 \u0628\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646\u060c \u0645\u0645\u0627 \u064a\u0624\u062f\u064a \u0625\u0644\u0649 \u0645\u0648\u062a \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0639\u0635\u0628\u064a\u0629\u061b \u0648\u062a\u064f\u0639\u062f \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0646 \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0624\u0634\u0631\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0625\u0635\u0627\u0628\u0629 \u0628\u0627\u0644\u0645\u0631\u0636 \u0623\u0648 \u062e\u0637\u0648\u0631\u0629 \u0627\u0644\u062a\u0639\u0631\u0636 \u0644\u0647. \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0189995 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"0189995\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-dna\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M.1 494.1c-1.1 9.5 6.3 17.8 15.9 17.8l32.3.1c8.1 0 14.9-5.9 16-13.9.7-4.9 1.8-11.1 3.4-18.1H380c1.6 6.9 2.9 13.2 3.5 18.1 1.1 8 7.9 14 16 13.9l32.3-.1c9.6 0 17.1-8.3 15.9-17.8-4.6-37.9-25.6-129-118.9-207.7-17.6 12.4-37.1 24.2-58.5 35.4 6.2 4.6 11.4 9.4 17 14.2H159.7c21.3-18.1 47-35.6 78.7-51.4C410.5 199.1 442.1 65.8 447.9 17.9 449 8.4 441.6.1 432 .1L399.6 0c-8.1 0-14.9 5.9-16 13.9-.7 4.9-1.8 11.1-3.4 18.1H67.8c-1.6-7-2.7-13.1-3.4-18.1-1.1-8-7.9-14-16-13.9L16.1.1C6.5.1-1 8.4.1 17.9 5.3 60.8 31.4 171.8 160 256 31.5 340.2 5.3 451.2.1 494.1zM224 219.6c-25.1-13.7-46.4-28.4-64.3-43.6h128.5c-17.8 15.2-39.1 30-64.2 43.6zM355.1 96c-5.8 10.4-12.8 21.1-21 32H114c-8.3-10.9-15.3-21.6-21-32h262.1zM92.9 416c5.8-10.4 12.8-21.1 21-32h219.4c8.3 10.9 15.4 21.6 21.2 32H92.9z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\tGPNMB (\u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0633\u0643\u0631\u064a B \u0627\u0644\u0645\u0631\u062a\u0628\u0637 \u0628\u0627\u0644\u0645\u064a\u0644\u0627\u0646\u0648\u0645\u0627 \u063a\u064a\u0631 \u0627\u0644\u0646\u0642\u064a\u0644\u064a\u0629)\t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\u0646\u0638\u0631\u0627\u064b \u0644\u062f\u0648\u0631\u0647 \u0627\u0644\u0645\u062a\u0639\u062f\u062f \u0641\u064a \u0645\u062e\u062a\u0644\u0641 \u0627\u0644\u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u0641\u0633\u064a\u0648\u0644\u0648\u062c\u064a\u0629\u060c \u0641\u0642\u062f \u0627\u0631\u062a\u0628\u0637 \u0628\u0631\u0648\u062a\u064a\u0646 GPNMB \u0628\u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0631\u0636\u064a\u0629\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0645\u0631\u0636 \u0623\u0644\u0632\u0647\u0627\u064a\u0645\u0631\u060c \u0648\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646\u060c \u0648\u062a\u0643\u0648\u0646 \u0627\u0644\u0623\u0648\u0631\u0627\u0645 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629\u060c \u0648\u062a\u0631\u0627\u0643\u0645 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0647\u0631\u0645\u0629\u060c \u0648\u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629.\n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc61c57 elementor-view-default elementor-position-block-start elementor-mobile-position-block-start elementor-widget elementor-widget-icon-box\" data-id=\"bc61c57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"icon-box.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-icon-box-wrapper\">\n\n\t\t\t\t\t\t<div class=\"elementor-icon-box-icon\">\n\t\t\t\t<span  class=\"elementor-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-virus\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M483.55,227.55H462c-50.68,0-76.07-61.27-40.23-97.11L437,115.19A28.44,28.44,0,0,0,396.8,75L381.56,90.22c-35.84,35.83-97.11,10.45-97.11-40.23V28.44a28.45,28.45,0,0,0-56.9,0V50c0,50.68-61.27,76.06-97.11,40.23L115.2,75A28.44,28.44,0,0,0,75,115.19l15.25,15.25c35.84,35.84,10.45,97.11-40.23,97.11H28.45a28.45,28.45,0,1,0,0,56.89H50c50.68,0,76.07,61.28,40.23,97.12L75,396.8A28.45,28.45,0,0,0,115.2,437l15.24-15.25c35.84-35.84,97.11-10.45,97.11,40.23v21.54a28.45,28.45,0,0,0,56.9,0V462c0-50.68,61.27-76.07,97.11-40.23L396.8,437A28.45,28.45,0,0,0,437,396.8l-15.25-15.24c-35.84-35.84-10.45-97.12,40.23-97.12h21.54a28.45,28.45,0,1,0,0-56.89ZM224,272a48,48,0,1,1,48-48A48,48,0,0,1,224,272Zm80,56a24,24,0,1,1,24-24A24,24,0,0,1,304,328Z\"><\/path><\/svg>\t\t\t\t<\/span>\n\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t<div class=\"elementor-icon-box-content\">\n\n\t\t\t\t\t\t\t\t\t<h3 class=\"elementor-icon-box-title\">\n\t\t\t\t\t\t<span  >\n\t\t\t\t\t\t\t\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a \u0645\u0646 \u0646\u0648\u0639 08-OHdG (8-\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a-2'-\u062f\u064a\u0648\u0643\u0633\u064a-\u063a\u0648\u0627\u0646\u0648\u0632\u064a\u0646): \t\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/h3>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<p class=\"elementor-icon-box-description\">\n\t\t\t\t\t\t\u064a\u064f\u0639\u062f 8-OHdG \u0645\u0624\u0634\u0631\u0627\u064b \u0639\u0644\u0649 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u060c \u0648\u064a\u0631\u062a\u0628\u0637 \u0628\u062a\u0644\u0641 \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a (\u0642\u0650\u0635\u064e\u0631 \u0627\u0644\u062a\u064a\u0644\u0648\u0645\u064a\u0631\u0627\u062a)\u061b \u0625\u0630 \u062a\u0634\u064a\u0631 \u0627\u0644\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0641\u0639\u0629 \u0645\u0646\u0647 \u0625\u0644\u0649 \u062e\u0637\u0631 \u0643\u0628\u064a\u0631 \u0644\u062d\u062f\u0648\u062b \u062a\u0644\u0641 \u0641\u064a \u0627\u0644\u062d\u0645\u0636 \u0627\u0644\u0646\u0648\u0648\u064a. \n\t\t\t\t\t<\/p>\n\t\t\t\t\n\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c06e434 e-con-full e-flex e-con e-parent\" data-id=\"c06e434\" data-element_type=\"container\" data-e-type=\"container\" id=\"#RPSBMSC-section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-959d88f e-flex e-con-boxed e-con e-child\" data-id=\"959d88f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-713602b elementor-widget elementor-widget-heading\" data-id=\"713602b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0645\u062c\u062f\u0651\u0650\u062f\u0629 \u062a\u0641\u0631\u0632\u0647\u0627 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 <\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5458fb3 elementor-widget elementor-widget-text-editor\" data-id=\"5458fb3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u064a\u062d\u062a\u0648\u064a \u0627\u0644\u0625\u0641\u0631\u0627\u0632 \u0627\u0644\u062e\u0644\u0648\u064a \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0639\u0644\u0649 \u0645\u0626\u0627\u062a \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u062a\u062c\u062f\u064a\u062f\u064a\u0629 \u0627\u0644\u0646\u0634\u0637\u0629 \u0630\u0627\u062a \u0627\u0644\u062e\u0635\u0627\u0626\u0635 \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0644\u0644\u0634\u064a\u062e\u0648\u062e\u0629\u060c \u0645\u062b\u0644 \u0646\u064a\u0628\u0631\u064a\u0644\u064a\u0633\u064a\u0646 (NEP) \u0648\u062c\u0627\u0644\u0627\u0643\u062a\u064a\u0646-1 \u0648\u0647\u064a\u062f\u0631\u0648\u0643\u0633\u064a\u0644 \u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 \u0643\u0627\u0631\u0628\u0648\u0643\u0633\u064a\u0644 \u0627\u0644\u0637\u0631\u0641\u064a L1 (UCH-L1).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d5e77c elementor-widget elementor-widget-text-editor\" data-id=\"1d5e77c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u064a\u064f\u0639\u062f \u0625\u0646\u0632\u064a\u0645 NEP \u0639\u0636\u0648\u0627\u064b \u0641\u064a \u0639\u0627\u0626\u0644\u0629 M13 \u0645\u0646 \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0627\u0644\u0628\u0628\u062a\u064a\u062f\u0627\u0632 \u0627\u0644\u0645\u0639\u062f\u0646\u064a\u0629 \u0627\u0644\u0645\u062d\u062a\u0648\u064a\u0629 \u0639\u0644\u0649 \u0627\u0644\u0632\u0646\u0643. \u064a\u064f\u0639\u0628\u0651\u064e\u0631 \u0639\u0646 \u0647\u0630\u0627 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0628\u0634\u0643\u0644 \u0631\u0626\u064a\u0633\u064a \u0641\u064a \u0627\u0644\u0643\u0644\u0649\u060c \u0625\u0644\u0627 \u0623\u0646\u0647 \u064a\u062a\u0648\u0627\u062c\u062f \u0628\u0645\u0633\u062a\u0648\u064a\u0627\u062a \u0623\u0642\u0644 \u0628\u0643\u062b\u064a\u0631 \u0641\u064a \u0627\u0644\u0639\u062f\u064a\u062f \u0645\u0646 \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0623\u062e\u0631\u0649\u060c \u0628\u0645\u0627 \u0641\u064a \u0630\u0644\u0643 \u0627\u0644\u062f\u0645\u0627\u063a. \u064a\u062a\u0648\u0627\u062c\u062f \u0625\u0646\u0632\u064a\u0645 &#8220;\u0646\u064a\u0628\u0631\u064a\u0644\u064a\u0633\u064a\u0646&#8221; (Neprilysin) \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a \u0636\u0645\u0646 \u0627\u0644\u0625\u0641\u0631\u0627\u0632\u0627\u062a \u0627\u0644\u062e\u0644\u0648\u064a\u0629 (secretome) \u0644\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 \u0627\u0644\u0645\u0634\u062a\u0642\u0629 \u0645\u0646 \u0627\u0644\u0646\u0633\u064a\u062c \u0627\u0644\u062f\u0647\u0646\u064a (ad-MSC)\u061b \u0648\u062a\u064f\u0646\u062a\u062c \u0647\u0630\u0647 \u0627\u0644\u0625\u0641\u0631\u0627\u0632\u0627\u062a -\u0633\u0648\u0627\u0621 \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 \u0623\u0648 \u062f\u0627\u062e\u0644 \u0627\u0644\u062c\u0633\u0645 \u0627\u0644\u062d\u064a- \u0643\u0648\u0633\u064a\u0644\u0629 \u0644\u0644\u062a\u0648\u0627\u0635\u0644 \u0628\u064a\u0646 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0648\u0643\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0644\u0644\u0645\u0624\u062b\u0631\u0627\u062a \u0627\u0644\u062e\u0627\u0631\u062c\u064a\u0629. \u0648\u064a\u0631\u062a\u0628\u0637 \u0625\u0646\u0632\u064a\u0645 NEP \u0628\u0623\u0634\u0643\u0627\u0644 &#8220;\u0623\u0648\u0644\u064a\u063a\u0648\u0645\u0631&#8221; (oligomers) \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0644\u0623\u0645\u064a\u0644\u0648\u064a\u062f-\u0628\u064a\u062a\u0627\u060c \u0645\u0645\u0627 \u064a\u062d\u0648\u0644 \u062f\u0648\u0646 \u062a\u0631\u0633\u0628\u0647\u0627.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a5565db elementor-widget elementor-widget-text-editor\" data-id=\"a5565db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u064a\u064f\u0646\u062a\u062c \u0628\u0631\u0648\u062a\u064a\u0646 &#8220;\u063a\u0627\u0644\u064a\u0643\u062a\u064a\u0646-1&#8221; (Galectin-1) \u0628\u0634\u0643\u0644 \u0637\u0628\u064a\u0639\u064a \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0644\u062d\u0645\u064a\u0629 (\u0627\u0644\u0645\u064a\u0632\u0646\u0634\u064a\u0645\u064a\u0629). \u0648\u064a\u064f\u0639\u062f \u0647\u0630\u0627 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646 \u0645\u0646 \u0641\u0626\u0629 \u0627\u0644\u0644\u064a\u0643\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u0631\u062a\u0628\u0637\u0629 \u0628\u0627\u0644\u062c\u0627\u0644\u0627\u0643\u062a\u0648\u0632\u061b \u0625\u0630 \u064a\u0639\u0645\u0644 \u0639\u0644\u0649 \u062d\u062c\u0628 \u0628\u0631\u0648\u062a\u064a\u0646 &#8220;\u0623\u0644\u0641\u0627-\u0633\u064a\u0646\u0648\u0643\u0644\u064a\u0646&#8221; (alpha-synuclein) \u0639\u0646\u062f \u063a\u0634\u0627\u0621 \u0627\u0644\u062e\u0644\u064a\u0629 \u0648\u064a\u062d\u0648\u0644 \u062f\u0648\u0646 \u062f\u062e\u0648\u0644\u0647 \u0625\u0644\u064a\u0647\u0627\u060c \u0645\u0645\u0627 \u064a\u0645\u0646\u0639 \u0627\u0644\u0645\u0633\u0627\u0631 \u0627\u0644\u0645\u0631\u0636\u064a \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0627\u0644\u0645\u0633\u0628\u0628 \u0644\u0645\u0631\u0636 \u0628\u0627\u0631\u0643\u0646\u0633\u0648\u0646.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a674f1a elementor-widget elementor-widget-text-editor\" data-id=\"a674f1a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u0625\u0646\u0632\u064a\u0645 \u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 \u0643\u0627\u0631\u0628\u0648\u0643\u0633\u064a\u0644-\u062a\u064a\u0631\u0645\u064a\u0646\u0627\u0644 \u0647\u064a\u062f\u0631\u0648\u0644\u0627\u0632 L1 \u0647\u0648 \u0623\u062d\u062f \u0625\u0646\u0632\u064a\u0645\u0627\u062a \u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 (DUB). \u064a\u0642\u0648\u0645 UCH-L1 \u0628\u0625\u0632\u0627\u0644\u0629 \u0627\u0644\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 \u0645\u0646 \u0627\u0644\u0645\u0648\u0627\u062f \u0627\u0644\u0645\u064f\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646\u064a\u0629\u060c \u0645\u0645\u0627 \u064a\u064f\u062a\u064a\u062d \u062a\u062d\u0644\u0644 \u0627\u0644\u0625\u0646\u0632\u064a\u0645 \u0627\u0644\u0645\u0633\u062a\u0647\u062f\u0641\u060c \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0625\u0639\u0627\u062f\u0629 \u062a\u062f\u0648\u064a\u0631 \u0627\u0644\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646 \u0627\u0644\u062d\u0631 \u0648\u062a\u062b\u0628\u064a\u062a\u0647. \u064a\u064f\u0633\u0631\u0651\u0639 UCH-L1 \u062a\u062d\u0644\u0644 BACE1\u060c \u0648\u064a\u0646\u0638\u0645 \u0628\u0631\u0648\u062a\u064a\u0646 \u0637\u0644\u064a\u0639\u0629 \u0627\u0644\u0623\u0645\u064a\u0644\u0648\u064a\u062f\u060c \u0648\u064a\u064f\u0642\u0644\u0644 \u0645\u0646 \u0625\u0646\u062a\u0627\u062c \u0628\u064a\u062a\u0627 \u0623\u0645\u064a\u0644\u0648\u064a\u062f \u0641\u064a \u0645\u0631\u0636 \u0627\u0644\u0632\u0647\u0627\u064a\u0645\u0631 \u0648\u0625\u0635\u0627\u0628\u0627\u062a \u0627\u0644\u062d\u0628\u0644 \u0627\u0644\u0634\u0648\u0643\u064a\u060c \u0648\u064a\u064f\u062b\u0628\u0637 \u062a\u0643\u0648\u0651\u0646 \u0644\u0648\u064a\u062d\u0627\u062a \u0639\u0635\u0628\u064a\u0629\u060c \u0648\u064a\u064f\u062d\u0633\u0651\u0646 \u0645\u0646 \u0642\u0635\u0648\u0631 \u0627\u0644\u0630\u0627\u0643\u0631\u0629 (\u0641\u064a \u0646\u0645\u0648\u0630\u062c \u0627\u0644\u0642\u0648\u0627\u0631\u0636). \u062a\u0631\u062a\u0628\u0637 \u0627\u0644\u062a\u0631\u0643\u064a\u0632\u0627\u062a \u0627\u0644\u0639\u0627\u0644\u064a\u0629 \u0645\u0646\u0647 \u0628\u0632\u064a\u0627\u062f\u0629 \u0645\u0648\u062a \u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062f\u0645\u0627\u063a.   <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-38d97ac e-con-full e-flex e-con e-parent\" data-id=\"38d97ac\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-41e22c5 e-flex e-con-boxed e-con e-child\" data-id=\"41e22c5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a4ba50a elementor-widget elementor-widget-heading\" data-id=\"a4ba50a\" data-element_type=\"widget\" data-e-type=\"widget\" id=\"COAAOP-section\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u062c\u0645\u0639\u0629 \u0648\u0627\u0644\u0645\u0624\u0643\u0633\u062f\u0629\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eee3ba8 elementor-widget elementor-widget-text-editor\" data-id=\"eee3ba8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u0628\u0634\u0643\u0644 \u0639\u0627\u0645\u060c \u062a\u062a\u0645\u062a\u0639 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0627\u0644\u0648\u0633\u064a\u0637\u0629 (MSCs) \u0648\u0645\u064f\u0641\u0631\u064e\u0632\u0627\u062a\u0647\u0627 (\u0627\u0644\u0633\u0643\u0631\u064a\u062a\u0648\u0645) \u0628\u0622\u0644\u064a\u0629 \u0639\u0645\u0644 \u062a\u062c\u062f\u064a\u062f\u064a\u0629\u061b \u0625\u0630 \u062a\u0624\u062b\u0631 \u0641\u064a \u062c\u0645\u064a\u0639 \u0623\u062c\u0647\u0632\u0629 \u0627\u0644\u062c\u0633\u0645 \u0645\u0646 \u062e\u0644\u0627\u0644 \u062a\u0646\u0634\u064a\u0637 \u0627\u0644\u0623\u0646\u0638\u0645\u0629 \u0627\u0644\u0645\u0633\u0624\u0648\u0644\u0629 \u0639\u0646 \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0631\u0648\u0627\u0633\u0628 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0627\u0644\u0645\u062a\u062c\u0645\u0639\u0629 \u0648\u0627\u0644\u0645\u0624\u0643\u0633\u062f\u0629 \u0627\u0644\u062a\u064a \u062a\u062a\u0631\u0627\u0643\u0645 \u0637\u0648\u0627\u0644 \u0641\u062a\u0631\u0629 \u062d\u064a\u0627\u0629 \u0627\u0644\u062e\u0644\u0627\u064a\u0627. \u0648\u064a\u0646\u062c\u0645 \u0647\u0630\u0627 \u0627\u0644\u062a\u0631\u0627\u0643\u0645 \u0639\u0646 \u0639\u0627\u0645\u0644\u064a\u0646: \u062a\u0632\u0627\u064a\u062f \u062d\u062f\u0648\u062b \u0627\u0644\u0636\u0631\u0631 \u0627\u0644\u0646\u0627\u062c\u0645 \u0639\u0646 \u0627\u0644\u0625\u062c\u0647\u0627\u062f \u0627\u0644\u062a\u0623\u0643\u0633\u062f\u064a\u060c \u0648\u0627\u0646\u062e\u0641\u0627\u0636 \u0643\u0641\u0627\u0621\u0629 \u0639\u0645\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u062e\u0644\u0635 \u0645\u0646 \u0647\u0630\u0647 \u0627\u0644\u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u0639\u0628\u0631 \u0622\u0644\u064a\u0627\u062a \u0627\u0644\u062a\u062d\u0644\u0644. \u0648\u062a\u062a\u0645 \u0639\u0645\u0644\u064a\u0629 \u0627\u0644\u062a\u062e\u0644\u0635 \u0627\u0644\u0631\u0626\u064a\u0633\u064a\u0629 (\u0628\u0646\u0633\u0628\u0629 70-80%) \u0639\u0628\u0631 \u0646\u0638\u0627\u0645 &#8220;\u064a\u0648\u0628\u064a\u0643\u0648\u064a\u062a\u064a\u0646-\u0628\u0631\u0648\u062a\u064a\u0627\u0632\u0648\u0645&#8221; (UPS).  <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b118e98 e-con-full e-flex e-con e-parent\" data-id=\"b118e98\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t<div class=\"elementor-element elementor-element-2613fb1 e-flex e-con-boxed e-con e-child\" data-id=\"2613fb1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2fa2c7e e-con-full e-flex e-con e-child\" data-id=\"2fa2c7e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-7d579ea e-con-full e-flex e-con e-child\" data-id=\"7d579ea\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-485708d elementor-widget elementor-widget-heading\" data-id=\"485708d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">\u0627\u0628\u062f\u0623 \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u0623\u0648\u0644\u0649 \u0627\u0644\u064a\u0648\u0645<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e3d16ba elementor-widget__width-initial elementor-widget-mobile__width-inherit elementor-widget elementor-widget-text-editor\" data-id=\"e3d16ba\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u0627\u0637\u0644\u0628 \u062a\u0642\u064a\u064a\u0645\u0627\u064b \u0645\u062c\u0627\u0646\u064a\u0627\u064b \u0644\u0633\u062c\u0644\u0643 \u0627\u0644\u0637\u0628\u064a \u0645\u0646 \u0642\u0650\u0628\u064e\u0644 \u0643\u0628\u0627\u0631 \u0623\u0637\u0628\u0627\u0626\u0646\u0627\u061b \u0627\u0644\u062e\u062f\u0645\u0629 \u0644\u0627 \u062a\u062a\u0631\u062a\u0628 \u0639\u0644\u064a\u0647\u0627 \u0623\u064a \u0627\u0644\u062a\u0632\u0627\u0645\u0627\u062a \u0623\u0648 \u062f\u0641\u0639 \u0645\u0633\u0628\u0642. <\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8b55056 elementor-align-center elementor-mobile-align-left elementor-widget elementor-widget-button\" data-id=\"8b55056\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/mesencell.com\/ar\/%d8%a7%d8%aa%d8%b5%d9%84-%d8%a8%d9%86%d8%a7%d8%a7%d8%aa%d8%b5%d9%84-%d8%a8%d9%86%d8%a7\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-long-arrow-alt-right\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M313.941 216H12c-6.627 0-12 5.373-12 12v56c0 6.627 5.373 12 12 12h301.941v46.059c0 21.382 25.851 32.09 40.971 16.971l86.059-86.059c9.373-9.373 9.373-24.569 0-33.941l-86.059-86.059c-15.119-15.119-40.971-4.411-40.971 16.971V216z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">\u0627\u062d\u062c\u0632 \u0627\u0633\u062a\u0634\u0627\u0631\u0629 <\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>\u0627\u0644\u0637\u0628 \u0627\u0644\u062a\u062c\u062f\u064a\u062f\u064a \u0627\u0644\u0645\u062a\u0642\u062f\u0645 \u0639\u0646\u0627\u064a\u0629 \u0645\u062a\u0642\u062f\u0645\u0629 \u0628\u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u062c\u0630\u0639\u064a\u0629 \u0645\u0646 \u0623\u062c\u0644 \u0645\u0633\u062a\u0642\u0628\u0644\u0643. \u0627\u0644\u0627\u0646\u062a\u0642\u0627\u0644 \u0645\u0646 \u0627\u0644\u062a\u0645\u064a\u0632 \u0627\u0644\u0628\u062d\u062b\u064a \u0625\u0644\u0649 \u062a\u062d\u0642\u064a\u0642 \u0646\u062a\u0627\u0626\u062c \u062a\u062a\u0645\u062d\u0648\u0631 \u062d\u0648\u0644 \u0627\u0644\u0645\u0631\u064a\u0636. \u0627\u0643\u062a\u0634\u0641 \u0639\u0644\u0627\u062c\u0627\u062a \u062a\u062c\u062f\u064a\u062f\u064a\u0629 \u0639\u0627\u0644\u0645\u064a\u0629 \u0627\u0644\u0645\u0633\u062a\u0648\u0649 \u0645\u0635\u0645\u0645\u0629 \u062e\u0635\u064a\u0635\u0627\u064b \u0644\u062a\u0644\u0628\u064a\u0629 \u0627\u0644\u0627\u062d\u062a\u064a\u0627\u062c\u0627\u062a \u0627\u0644\u0645\u062a\u0639\u0644\u0642\u0629 \u0628\u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0639\u0638\u0627\u0645\u060c \u0648\u0623\u0645\u0631\u0627\u0636 \u0627\u0644\u0645\u0646\u0627\u0639\u0629 \u0627\u0644\u0630\u0627\u062a\u064a\u0629\u060c \u0648\u0645\u0643\u0627\u0641\u062d\u0629 \u0627\u0644\u0634\u064a\u062e\u0648\u062e\u0629. \u062a\u062d\u0645\u064a\u0644 \u0627\u0644\u062f\u0644\u064a\u0644 \u0627\u0644\u0645\u0641\u0635\u0644 \u062a\u062d\u0645\u064a\u0644 \u0627\u0644\u062f\u0644\u064a\u0644 \u0627\u0644\u0645\u0641\u0635\u0644 \u0634\u064a\u062e\u0648\u062e\u0629 \u0645\u0639 \u0627\u0644\u0627\u0631\u062a\u0641\u0627\u0639 \u0627\u0644\u0645\u0633\u062a\u0645\u0631 \u0641\u064a \u0645\u062a\u0648\u0633\u0637 \u200b\u200b\u0627\u0644\u0639\u0645\u0631 \u0627\u0644\u0645\u062a\u0648\u0642\u0639\u060c \u064a\u062a\u0632\u0627\u064a\u062f \u0623\u064a\u0636\u0627\u064b \u062a\u0623\u062b\u064a\u0631 \u0627\u0644\u0623\u0645\u0631\u0627\u0636 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-8641","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/pages\/8641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/comments?post=8641"}],"version-history":[{"count":4,"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/pages\/8641\/revisions"}],"predecessor-version":[{"id":8974,"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/pages\/8641\/revisions\/8974"}],"wp:attachment":[{"href":"https:\/\/mesencell.com\/ar\/wp-json\/wp\/v2\/media?parent=8641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}